Wir erforschen in vivo die Interaktion von Lymphozyten mit Fokus auf dendritische Zellen und DC–T-Zell-Wechselwirkungen. In humanen Krankheitsmodellen untersuchen wir ihre Rolle in Immunität und Toleranz sowie extrazelluläre Vesikel als Biomarker und Immunmodulatoren.
© J. Greune / LMU
Prof. Dr. Thomas Brocker
Direktor, Institut für Immunologie
Biomedizinisches Centrum München
Großhadernerstr. 9
DE- 82152 Planegg-Martinsried
+49 (0)89 2180 75674
tbrocker@med.uni-muenchen.de
Sekretariat: Marion Dorfmeister
+49 89 2180-75669
sekretariat.immunologie@med.uni-muenchen.de
Extracellular vesicles (EVs) modulate immune responses, although there is still little direct evidence in vivo for such a mechanism. We develop novel methods and reagents to analyze cells associated with EVs in infected mice and humans. We focus on effector T cells and other PBMC which strongly bind Evs and study the capacities of EVs to drive T-cell-fate decisions.
needs text
needs text
Phosphatidylserine (PS) is a plasma membrane component actively retained at the inner membrane surface in living cells. PS retention stops, for example, during cell death or when cells release PS-containing microparticles. Then PS relocates to the outer layer of the cell membrane, where it can interact with extracellular proteins. PS causes thrombin formation, coagulation, activation of the complement system, and inflammation. We study the contribution of these processes to inflammation, immunity, and pathology.
Apoptotic cell clearance is essential to avoid autoimmunity. C1q deficiency results in systemic lupus erythematosus (SLE). However, the mechanisms in SLE development are still unclear. We have developed novel tools to analyze the waste disposal hypothesis, the removal process of dying cells in vivo in a model to study the disease mechanisms and to identify susceptibility factors.
Wir nutzen neuartige rekombinante Moleküle, die spezifisch für sterbende Zellen, Mikropartikel, extrazelluläre Vesikel und Thrombozyten sind, um Werkzeuge für Forschung und Entwicklung, Diagnostik sowie für die experimentelle Therapie von Krebs, Autoimmunerkrankungen und für Impfungen zu entwickeln.
https://orcid.org/0000-0001-7060-5433
Stutte, S., Ruf, J., Kugler, I., Ishikawa-Ankerhold, H., Parzefall, A., Marconi, P., Maeda, T., Kaisho T., Krug, A., Popper, B., Lauterbach, H., Colonna, M., von Andrian, U., Brocker, T. (2021) Type I interferon mediated induction of somatostatin leads to suppression of ghrelin and appetite thereby promoting viral immunity in mice. Brain, Behavior and Immunity (online preprint 23 Apr 2021) https://doi.org/10.1016/j.bbi.2021.04.018
Kranich, J., Chlis, N.K., Rausch, L., Latha, A., Schifferer, M., Kurz, T., Foltyn-Arfa Kia, A., Simons, M., Theis, F.J., and Brocker, T. (2020). In vivo identification of apoptotic and extracellular vesicle-bound live cells using image-based deep learning. J Extracell Vesicles 9:1792683. https://www.ncbi.nlm.nih.gov/pubmed/32944180
Barthels, C., Ogrinc, A., Steyer, V., Meier, S., Simon, F., Wimmer, M., Blutke, A., Straub, T., Zimber-Strobl, U., Lutgens, E., Marconi, P., Ohnmacht, C., Garzetti, D., Stecher, B., and Brocker, T. (2017b). CD40-signalling abrogates induction of RORgammat(+) Treg cells by intestinal CD103(+) DCs and causes fatal colitis. Nat Commun 8:14715. https://www.ncbi.nlm.nih.gov/pubmed/28276457
Bernhard, C.A., Ried, C., Kochanek, S., and Brocker, T. (2015). CD169+ macrophages are sufficient for priming of CTLs with specificities left out by cross-priming dendritic cells. Proc Natl Acad Sci U S A 112:5461-5466. https://www.ncbi.nlm.nih.gov/pubmed/25922518
Kellersch, B., and Brocker, T. (2013). Langerhans cell homeostasis in mice is dependent on mTORC1 but not mTORC2 function. Blood 121:298-307. https://www.ncbi.nlm.nih.gov/pubmed/23212520
| Name | Titel | Position | |
|---|---|---|---|
| Brocker, Thomas | Prof. Dr. rer. nat. | Gruppenleiter Direktor, Institut f. Immunologie | tbrocker@med.uni-muenchen.de |
| Arensmeier, Laura | Assistant Offfice Manager | laura.arensmeier@med.uni-muenchen.de | |
| Dorfmeister, Marion | Office Manager | Marion.Dorfmeister@lmu.de | |
| Guvencli, Nese | MSc | Doktorandin | nese.guevencli@med.lmu.de |
| Kranich, Jan | PD Dr. rer. nat. | Projektleiter, Referent? | jan.kranich@med.uni-muenchen.de |
| Mathur, Riya | MSc | Doktorandin | Riya.Mathur@med.uni-muenchen.de |
| Prechtl, Monica | MSc | Doktorandin | Monica.Prechtl@med.uni-muenchen.de |
| Rauter, Beatrice | TA | Technische Assistentin | beatrice.rauter(@med.uni-muenchen.de |
| Ried, Christine | TA | Technische Assistentin | christine.ried@med.uni-muenchen.de |
| Scheck, Annkathrin | MSc | Doktorandin | Annkathrin.Scheck@med.uni-muenchen.de |
| Schroeder-Reiter, Elizabeth | Dr. rer. nat. | Koordinatorin | e.schroeder-reiter@lmu.de |